Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary TargetIGF-1

Cell permeable: yes

General description

A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC₅₀ values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.

A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC₅₀ values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wen, B., et al. 2001. Br. J. Cancer85, 2017.Parrizas, M., et al. 1997. Endocrinology138, 1427.Ohmichi, M., et al. 1993. Biochemistry32, 4650.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.

Warning

Toxicity: Standard Handling (A)